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Biological Sexing of a 4000-Year-Old Egyptian Mummy 2018 O.K., Djehutynakht U5b2b5

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    Biological Sexing of a 4000-Year-Old Egyptian Mummy 2018 O.K., Djehutynakht U5b2b5

    "Given limited available data and the fact that U5 is the dominant mitochondrial haplogroup found among hunter-gatherers in Europe [83,84], the recovery of a haplogroup U5b2b5 sequence from the mummy of Djehutynakht [...]... the observed U5 lineage could potentially reflect interactions between Egypt and the Near East that date as far back as the Predynastic and Early Dynastic periods [85]. Trade between Egypt and the Near East is evidenced by, among other things, ceramic imports to Egypt [86]. In addition, dwellings similar to those found in Palestine suggest some immigration to Egypt from more arid Near Eastern areas from the late Predynastic to the Old Kingdom [85,87]. Both trade and immigration between Egypt and the Near East continued to increase over time. Demand in Egypt for cedar of Lebanon wood (a wood available and harvested in Lebanon and Syria during the MK) led to the further establishment of trade routes between Egypt and the Levant [85,86]. It is interesting, and perhaps not coincidental, that the individual with the mtDNA sequence most similar to Djehutynakht comes from a Lebanese individual. ... In fact, of the 114 mtDNA genomes now available from northern African ancient human remains, only one belongs to an African lineage (L3 observed in a skeleton from Abusir el-Meleq [74]). The deep presence of Eurasian mtDNA lineages in Northern Africa has, therefore, been clearly established with these recent reports and offers further support for the authenticity of the Eurasian mtDNA sequence observed in the Djehutynakht mummy. In the present study, Near Eastern influence has been found in an individual of high social status who lived in Upper Egypt during the Middle Kingdom."

    The Djehutynakht sequence most closely resembles a U5a lineage from sample JK2903, a 2000-year-old skeleton from Abusir el-Meleq [74].

    (Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens 2018)

    http://www.mdpi.com/2073-4425/9/3/135/htm
    Genes | Free Full-Text | Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens
    http://www.mdpi.com
    High throughput sequencing (HTS) has been used for a number of years in the field of paleogenomics to facilitate the recovery of small DNA fragments from ancient specimens. Recently, these techniques have also been applied in forensics, where they have been used for the recovery of mitochondrial DNA sequences from samples where traditional PCR-based assays fail because of the very short length of endogenous DNA molecules. Here, we describe the biological sexing of a ~4000-year-old Egyptian mummy using shotgun sequencing and two established methods of biological sex determination (RX and RY), by way of mitochondrial genome analysis as a means of sequence data authentication. This particular case of historical interest increases the potential utility of HTS techniques for forensic purposes by demonstrating that data from the more discriminatory nuclear genome can be recovered from the most damaged specimens, even in cases where mitochondrial DNA cannot be recovered with current PCR-based forensic technologies. Although additional work remains to be done before nuclear DNA recovered via these methods can be used routinely in operational casework for individual identification purposes, these results indicate substantial promise for the retrieval of probative individually identifying DNA data from the most limited and degraded forensic specimens.
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